Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | AOC2 | O75106 | 1/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503401 | 0.81 | ALOX15 (0.65) | NPC1RAB9ALMNAMAPTGAA | |
| SCHEMBL11177157 | 0.81 | NPC1 (0.54) | NPC1RAB9ALMNAMAPTGAA | |
| SCHEMBL28684003 | 0.81 | NPC1 (0.54) | NPC1RAB9ALMNAMAPTGAA | |
| SCHEMBL10968825 | 0.81 | LTA4H (0.45) | RAB9ALMNAMAPTALOX15 | |
| SCHEMBL5107568 | 0.79 | MAOB (0.54) | NPC1RAB9ALMNAMAPTGAA | |
| SCHEMBL1619089 | 0.79 | NPC1 (0.53) | NPC1RAB9ALMNAMAPTGAA | |
| SCHEMBL4947908 | 0.79 | LMNA (0.56) | NPC1RAB9ALMNAMAPTGAA | |
| SCHEMBL4948856 | 0.79 | WDR5 (0.60) | NPC1LMNAMAPTGAAKMT2A | |
| SCHEMBL4946959 | 0.79 | ATF4 (0.53) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL4948738 | 0.79 | POLB (0.54) | MAPTKMT2AMEN1MAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329454-A | Cephalosporin compounds | ELI LILLY AND COMPANY (US) | 1982-05-11 | — | — | US | disclosed |
| US-4144391-A | REPLACING AN ACETOXY GROUP BY A SULFUR NUCLEOPHILE | ELI LILLY AND COMPANY (US) | 1979-03-13 | — | — | US | disclosed |