Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | TACR1 | P25103 | 9/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11155552 | 0.85 | OPRM1 (0.49) | SLC6A4OPRM1OPRL1KCNH2OPRD1 | |
| Hydrochloric Acid SCHEMBL11153301 | 0.84 | OPRM1 (0.47) | SLC6A4OPRM1OPRL1KCNH2OPRD1 | |
| SCHEMBL10512960 | 0.83 | TACR1 (0.52) | DRD2TACR1OPRM1OPRL1 | |
| SCHEMBL11737881 | 0.82 | POLB (0.55) | DRD2TACR1SLC6A4OPRM1OPRL1 | |
| SCHEMBL11155388 | 0.81 | OPRM1 (0.46) | SLC6A4OPRM1OPRL1KCNH2OPRD1 | |
| SCHEMBL10514541 | 0.81 | THRB (0.41) | DRD2TACR1OPRM1OPRL1HSD11B1 | |
| SCHEMBL10515742 | 0.80 | OPRM1 (0.44) | DRD2TACR1OPRM1OPRL1KCNH2 | |
| SCHEMBL10513647 | 0.80 | TRPM8 (0.43) | DRD2TACR1OPRM1OPRL1 | |
| SCHEMBL7342703 | 0.80 | TACR1 (0.52) | DRD2TACR1SLC6A4OPRM1OPRL1 | |
| SCHEMBL11740042 | 0.79 | CYP3A4 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4325953-A | 4-Aryl-4-aryloxypiperidines | JOHN WYETH AND BROTHER LIMITED (GB) | 1982-04-20 | — | — | US | claimed |
| US-4325953-A | 4-Aryl-4-aryloxypiperidines | JOHN WYETH AND BROTHER LIMITED (GB) | 1982-04-20 | — | — | US | disclosed |