Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10512960 | 0.88 | TACR1 (0.52) | THRBTACR1DRD2EPHX2EPHX1 | |
| SCHEMBL11740042 | 0.86 | CYP3A4 (0.48) | ALDH1A1TP53 | |
| SCHEMBL10515742 | 0.85 | OPRM1 (0.44) | THRBTACR1DRD2EPHX2EPHX1 | |
| SCHEMBL10513647 | 0.85 | TRPM8 (0.43) | THRBTACR1DRD2EPHX2OPRM1 | |
| SCHEMBL10515488 | 0.83 | TACR1 (0.49) | TACR1DRD2EPHX2ALDH1A1OPRM1 | |
| SCHEMBL10515329 | 0.81 | TRPM8 (0.57) | THRBEPHX2TRPM8 | |
| SCHEMBL11224032 | 0.81 | DRD2 (0.50) | TACR1DRD2OPRM1OPRL1OPRD1 | |
| SCHEMBL10513531 | 0.80 | MGLL (0.43) | KDM4EALDH1A1GAA | |
| SCHEMBL10515128 | 0.77 | ALDH1A1 (0.43) | KDM4EALDH1A1GAAOPRM1OPRD1 | |
| SCHEMBL11737881 | 0.77 | POLB (0.55) | TACR1DRD2KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | claimed |
| EP-0333025-A1 | 1-Carbonylderivatives of 4-aryl-4-aryloxypiperidines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-20 | — | — | EP | disclosed |
| US-4853384-A | ANTICONVULSANTS; | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1989-08-01 | — | — | US | disclosed |