Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11466969 | 0.84 | MAPT (0.54) | PTGESTP53MAPTLMNAMEN1 | |
| SCHEMBL11240864 | 0.82 | NPSR1 (0.64) | PTGESTP53MAPTLMNAALDH1A1 | |
| SCHEMBL11485886 | 0.81 | PTGES (0.47) | PTGESTP53MAPTLMNAALDH1A1 | |
| SCHEMBL31582542 | 0.80 | MAPT (0.58) | PTGESTP53MAPTLMNAALDH1A1 | |
| SCHEMBL11475686 | 0.78 | NPSR1 (0.42) | PTGESTP53MAPTALDH1A1MEN1 | |
| SCHEMBL11231108 | 0.78 | PTGES (0.71) | PTGESTP53MAPTLMNAALDH1A1 | |
| SCHEMBL11719116 | 0.77 | NPSR1 (0.57) | PTGESTP53MAPTMEN1KMT2A | |
| SCHEMBL11244831 | 0.76 | PTGES (0.80) | PTGESTP53MAPTLMNAALDH1A1 | |
| SCHEMBL11247823 | 0.76 | ALDH1A1 (0.49) | PTGESTP53MAPTLMNAALDH1A1 | |
| SCHEMBL11479414 | 0.75 | HPGD (0.44) | PTGESTP53MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4318911-A | 5,6-Diaryl-1,2,4-triazines as topical antithrombotic agents | ELI LILLY AND COMPANY (US) | 1982-03-09 | — | — | US | disclosed |
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |