Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11485886 | 0.89 | PTGES (0.47) | MAPTTP53LMNAKDM4EPTGES | |
| SCHEMBL11230698 | 0.84 | PTGES (0.56) | MAPTTP53LMNAKDM4EMEN1 | |
| SCHEMBL11477773 | 0.84 | NPSR1 (0.58) | MAPTTP53LMNAPTGESCACNA2D1 | |
| SCHEMBL11476250 | 0.82 | MAPT (0.59) | MAPTTP53LMNAKDM4EPTGES | |
| SCHEMBL11475990 | 0.80 | PTGES (0.62) | MAPTTP53LMNAKDM4EPTGES | |
| SCHEMBL11468271 | 0.79 | PTGES (0.52) | MAPTTP53LMNAKDM4EPTGES | |
| SCHEMBL11240284 | 0.79 | PTGES (0.57) | MAPTTP53LMNAPTGESCACNA2D1 | |
| SCHEMBL11468314 | 0.79 | PTGES (0.45) | MAPTTP53LMNAKDM4EPTGES | |
| SCHEMBL11477369 | 0.78 | CACNA2D1 (0.45) | MAPTTP53LMNAKDM4EMEN1 | |
| SCHEMBL11479414 | 0.77 | HPGD (0.44) | MAPTTP53LMNAPTGESNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4190725-A | ANTIINFLAMMATORY | ELI LILLY AND COMPANY (US) | 1980-02-26 | — | — | US | disclosed |
| US-4021553-A | 5,6-Diaryl-1,2,4-triazines as topically-active anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1977-05-03 | — | — | US | disclosed |