Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11237397 | 0.88 | DPP7 (0.38) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL29524977 | 0.76 | ALDH1A1 (0.41) | ALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL31503973 | 0.74 | TSHR (0.50) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL11643646 | 0.73 | ALDH1A1 (0.44) | ALDH1A1POLBHTTSMN1; SMN2CHRM2 | |
| SCHEMBL3150494 | 0.73 | CA2 (0.39) | ALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL1405404 | 0.73 | — | — | |
| SCHEMBL14243233 | 0.72 | SLC6A15 (0.36) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL8720475 | 0.72 | ALDH1A1 (0.40) | ALDH1A1POLBHTTSMN1; SMN2GAA | |
| SCHEMBL3662063 | 0.72 | ALDH1A1 (0.36) | ALDH1A1POLBHTTSMN1; SMN2CHRM2 | |
| SCHEMBL11242858 | 0.72 | ALDH1A1 (0.37) | ALDH1A1POLBCHRM2CHRM4CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4320137-A | Derivatives of perhydro-aza-heterocycles | CIBA-GEIGY CORPORATION (US) | 1982-03-16 | — | — | US | disclosed |
| US-4246269-A | Antidepressant piperidinones | CIBA-GEIGY CORPORATION (US) | 1981-01-20 | — | — | US | disclosed |
| US-4160837-A | ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1979-07-10 | — | — | US | disclosed |