SCHEMBL11232302

SCHEMBL11232302

Cc1[c][nH]c2ccc(-c3ccccc3)cc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 2/20 0.45
TNKS2 Q9H2K2 1/20 0.42
MKNK1 Q9BUB5 1/20 0.41
NPC1 O15118 2/20 0.41
NR4A2 P43354 1/20 0.40
HTR7 P34969 1/20 0.39
HTR6 P50406 1/20 0.39
GSK3B P49841 2/20 0.39
DYRK3 O43781 1/20 0.39
CLK1 P49759 1/20 0.39
CLK2 P49760 1/20 0.39
CLK3 P49761 1/20 0.39
CDK5 Q00535 1/20 0.39
DYRK1A Q13627 1/20 0.39
CDK5R1 Q15078 1/20 0.39
DYRK2 Q92630 1/20 0.39
CLK4 Q9HAZ1 1/20 0.39
DYRK1B Q9Y463 1/20 0.39
AXL P30530 1/20 0.38
CDK4 P11802 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL699552 0.84 TNKS2 (0.44) TNKS2GSK3BDYRK1AKDM4EMEN1
SCHEMBL316411 0.75 ALDH1A1 (0.41) NPC1KDM4EMEN1GAAMAPT
SCHEMBL546371 0.74 CYP1A2 (0.42) TNKS2KDM4EMEN1GAAMAPT
SCHEMBL699788 0.72 KIF11 (0.44) NPC1KDM4EGAAMAPTKMT2A
SCHEMBL701885 0.72 LMNA (0.46) NPC1NR4A2HTR7HTR6MEN1
SCHEMBL20933098 0.70 BCHE (0.53) JAK2TNKS2MKNK1NPC1HTR7
SCHEMBL722138 0.70 HAVCR2 (0.49)
SCHEMBL17154708 0.70 CDK4 (0.57) JAK2TNKS2MKNK1NPC1NR4A2
SCHEMBL12001022 0.70 CDK4 (0.57) JAK2TNKS2MKNK1NPC1NR4A2
SCHEMBL3365890 0.70 CDK4 (0.57) JAK2TNKS2MKNK1NPC1NR4A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4326065-A PLASTICS, VARNISHES, POLYESTERS EASTMAN KODAK COMPANY (US) 1982-04-20 US disclosed
US-4251433-A BENZOTRIAZOLE DERIVATIVES; FOR POLYMERS EASTMAN KODAK COMPANY (US) 1981-02-17 US disclosed
US-4236013-A ADDITIVES FOR POLYMERS EASTMAN KODAK COMPANY (US) 1980-11-25 US disclosed
US-4182703-A Biheterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1980-01-08 US disclosed
US-4172081-A Benzotriazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-10-23 US disclosed
US-4162254-A Benzoxazole ultraviolet stabilizers EASTMAN KODAK COMPANY (US) 1979-07-24 US disclosed
US-4141884-A PIPERIDINYL ESTERS OF HETEROCARBOXYLIC ACIDS EASTMAN KODAK COMPANY (US) 1979-02-27 US disclosed
US-4137235-A ULTRAVIOLET STABILIZERS IN POLYMERIC COMPOSITIONS EASTMAN KODAK COMPANY (US) 1979-01-30 US disclosed
US-4116929-A POLYESTERS EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4116928-A Heterocylic ester, ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1978-09-26 US disclosed
US-4096115-A Ultraviolet light stabilized polymers EASTMAN KODAK COMPANY (US) 1978-06-20 US disclosed
US-4065427-A Polychromophoric heterocyclic ultraviolet stabilizers and their use in organic compositions EASTMAN KODAK COMPANY (US) 1977-12-27 US disclosed
US-4017508-A POLYMERS EASTMAN KODAK COMPANY (US) 1977-04-12 US disclosed
US-4000148-A POLYMERS EASTMAN KODAK COMPANY (US) 1976-12-28 US disclosed