SCHEMBL11233129

SCHEMBL11233129

O=C(OC(c1cccnc1)C(Cl)(Cl)Cl)c1ccccc1Br

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.41
HPGD P15428 1/20 0.41
GAA P10253 2/20 0.39
KDM4E B2RXH2 1/20 0.37
ALDH1A1 P00352 1/20 0.37
MIF P14174 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
KCNH2 Q12809 1/20 0.36
CYP19A1 P11511 3/20 0.36
CYP17A1 P05093 2/20 0.36
TBXAS1 P24557 1/20 0.36
CFTR P13569 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
SLC6A3 Q01959 1/20 0.36
GOPC Q9HD26 1/20 0.36
HTT P42858 1/20 0.35
MAPK1 P28482 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11231758 0.91 TSHR (0.44) TSHRHPGDGAAKDM4EALDH1A1
SCHEMBL11252785 0.86 SMN1; SMN2 (0.48) HPGDGAAALDH1A1SMN1; SMN2CYP19A1
SCHEMBL11235465 0.85 GAA (0.47) GAAKDM4EALDH1A1SMN1; SMN2HTT
SCHEMBL11238290 0.83 CYP3A4 (0.44) GAACFTRSLC6A2SLC6A4
SCHEMBL11248372 0.82 PLOD2 (0.44) TSHRGAAALDH1A1SMN1; SMN2CFTR
SCHEMBL11236103 0.80 SMN1; SMN2 (0.49) HPGDGAAKDM4EALDH1A1SMN1; SMN2
SCHEMBL11244188 0.79 RAB9A (0.52) HPGDKDM4EALDH1A1SMN1; SMN2CYP19A1
SCHEMBL11228700 0.77 ALDH1A1 (0.45) GAAALDH1A1SMN1; SMN2CYP19A1CYP17A1
SCHEMBL11245560 0.75 CYP3A4 (0.41) GAAALDH1A1SMN1; SMN2CFTRSLC6A2
SCHEMBL11241260 0.74 LMNA (0.43) GAAALDH1A1SMN1; SMN2CYP19A1CYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4339455-A 1-(3-Pyridyl)-2,2,2-trihaloethyl compounds and fungicidal compositions containing the same CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1982-07-13 US disclosed
US-4189486-A FUNGICIDES CONSORTIUM FUR ELEKTROCHEMISCHE INDUSTRIE GMBH (DE) 1980-02-19 US disclosed