Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Phthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | HPGD | P15428 | 2/20 | 0.65 |
| ▸ | CA2 | P00918 | 6/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | BLM | P54132 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PKLR | P30613 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phthalic Acid SCHEMBL4506080 | 1.00 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL5279211 | 0.97 | ALDH1A1 (0.62) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL64136 | 0.97 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL195821 | 0.97 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL32678845 | 0.97 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL32678844 | 0.97 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL32678846 | 0.97 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL3385753 | 0.94 | ALDH1A1 (0.65) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL28409980 | 0.94 | ALDH1A1 (0.71) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Phthalic Acid SCHEMBL30001010 | 0.94 | ALDH1A1 (0.64) | ALDH1A1KDM4EHPGDCA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4345031-A | OXIDATION OF GLUCOSE TO GLUCONIC ACID | SOLVAY & CIE. (BE) | 1982-08-17 | — | — | US | disclosed |