Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 1/20 | 0.36 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233359 | 0.85 | ALDH1A1 (0.45) | ALDH1A1HTR2CSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL9391305 | 0.84 | ALDH1A1 (0.45) | ALDH1A1HTR2CSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL6870816 | 0.82 | MEN1 (0.49) | SYKMAPK1L3MBTL1KMT2ATDP1 | |
| SCHEMBL16458943 | 0.73 | CA12 (0.34) | CTSLMAPK1L3MBTL1KMT2A | |
| SCHEMBL4160510 | 0.72 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL13101483 | 0.72 | HTR2C (0.49) | ALDH1A1HTR2CSMN1; SMN2CTSLL3MBTL1 | |
| SCHEMBL5315958 | 0.72 | CTSK (0.40) | SLC6A2SLC6A3 | |
| SCHEMBL6645967 | 0.71 | ALDH1A1 (0.58) | ALDH1A1SYKSMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL696626 | 0.71 | CYP3A4 (0.40) | ALDH1A1SYKSMN1; SMN2CTSLL3MBTL1 | |
| SCHEMBL2980978 | 0.70 | ALDH1A1 (0.39) | ALDH1A1SYKSMN1; SMN2CTSLMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621270-B1 | Piperazine derivatives as collagenase inhibitors | SANKYO CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-4808713-A | Anthypertensive pyridazo [1,2-a][1,2]diazepines | HOFFMAN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| US-4772701-A | Pyridazo[1,2]pyridazines and pyrazolo[1,2]pyridazines as antihypertensives | HOFFMANN-LA ROCHE INC. (US) | 1988-09-20 | — | — | US | disclosed |
| US-4658024-A | Pyrazolo [1,2-a][1,2]-diazepines useful as antihypertensives | HOFFMANN-LA ROCHE INC. (US) | 1987-04-14 | — | — | US | disclosed |
| US-4512924-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1985-04-23 | — | — | US | disclosed |
| US-4487929-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE, INC. (US) | 1984-12-11 | — | — | US | disclosed |
| EP-0094095-A2 | Bicyclic carboxylic acids and their alkyl and aralkyl esters | F. HOFFMANN-LA ROCHE AG (CH) | 1983-11-16 | — | — | EP | disclosed |
| US-4399136-A | Pyrazolopyridazine antihypertensives | HOFFMANN-LA ROCHE INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4341781-A | HYPOTENSIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-07-27 | — | — | US | disclosed |
| EP-0042100-A1 | Pyrazolopyridazine derivatives, intermediates and processes for their preparation, and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1981-12-23 | — | — | EP | disclosed |