Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8216557 | 0.82 | ALDH1A1 (0.42) | KMT2ASYKTDP1MAPK1POLB | |
| SCHEMBL14485285 | 0.80 | SYK (0.62) | MEN1KMT2ANTSR1SYKMAPT | |
| SCHEMBL7770018 | 0.79 | L3MBTL1 (0.47) | MEN1KMT2AMAPTTDP1GPR55 | |
| SCHEMBL11233359 | 0.76 | ALDH1A1 (0.45) | MEN1KMT2ATDP1MAPK1L3MBTL1 | |
| SCHEMBL3838871 | 0.76 | CA12 (0.63) | MEN1KMT2ASYKNAMPTHDAC1 | |
| SCHEMBL6288470 | 0.76 | SYK (0.57) | MEN1KMT2ANTSR1SYKMAPT | |
| SCHEMBL9391305 | 0.75 | ALDH1A1 (0.45) | KMT2ATDP1MAPK1CA12CA7 | |
| SCHEMBL3940116 | 0.74 | NAMPT (0.60) | MEN1KMT2ANTSR1SYKMAPT | |
| SCHEMBL7766570 | 0.74 | MEN1 (0.41) | MEN1KMT2ANTSR1SYKMAPT | |
| SCHEMBL15873960 | 0.74 | SYK (0.50) | MEN1KMT2ANTSR1SYKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1244643-B1 | TRYPTASE INHIBITORS | ALTANA PHARMA AG (DE) | 2004-06-16 | — | — | EP | disclosed |
| EP-1244643-A1 | TRYPTASE INHIBITORS | ALTANA Pharma AG (DE) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001046168-A1 | TRYPTASE INHIBITORS | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 2001-06-28 | — | — | WO | disclosed |