Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 5/20 | 0.40 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | TYMS | P04818 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | PNP | P00491 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11261653 | 0.90 | PDE5A (0.46) | PDE5APARP1XDHPNP | |
| SCHEMBL11400581 | 0.79 | PDE2A (0.45) | TYMSPNP | |
| SCHEMBL11221750 | 0.73 | PLK4 (0.35) | PDE5APARP1 | |
| SCHEMBL14537118 | 0.73 | — | — | |
| SCHEMBL11395255 | 0.73 | LMNA (0.45) | PDE5APNP | |
| SCHEMBL6708585 | 0.73 | CDK4 (0.52) | PDE5APARP1 | |
| SCHEMBL11274435 | 0.72 | XDH (0.55) | PARP1TYMSXDH | |
| SCHEMBL11221751 | 0.71 | KDM4E (0.33) | PDE5A | |
| SCHEMBL11406006 | 0.70 | MEN1 (0.44) | PDE5ATYMSXDHPNP | |
| SCHEMBL24709355 | 0.69 | CHRNB2 (0.45) | TYMSXDHPNPNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0000383-B1 | PYRIMIDO (4,5-C) PYRIDAZINES, THEIR USE IN PHARMACEUTICAL PREPARATIONS, AND PROCESS FOR THEIR PREPARATION | THE WELLCOME FOUNDATION LIMITED (GB) | 1982-10-13 | — | — | EP | disclosed |
| US-4329362-A | INHIBITORS OF DIHYDROPTEROIC AND BIOSYNTHESES | BURROUGHS WELLCOME CO. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4323679-A | CHEMICAL INTERMEDIATES | BURROUGHS WELLCOME CO. (US) | 1982-04-06 | — | — | US | disclosed |
| US-4303790-A | INHIBITORS OF DIHYDROPTERIC ACID AND BIOSYNTHESIS | BURROUGHS WELLCOME CO. (US) | 1981-12-01 | — | — | US | disclosed |
| US-4303789-A | INHIBITORS OF DIHYDROPTERIC ACID AND BIOSYNTHESIS | BURROUGHS WELLCOME CO. (US) | 1981-12-01 | — | — | US | disclosed |
| US-4302587-A | INTERMEDIATE FOR ENZYME INHIBITING PYRIMIDO(4,5-C)PYRIDAZINES | BURROUGHS WELLCOME CO. (US) | 1981-11-24 | — | — | US | disclosed |
| US-4255427-A | TREATMENT OF COCCIDIOSIS IN POULTRY | BURROUGHS WELLCOME CO. (US) | 1981-03-10 | — | — | US | disclosed |
| US-4225710-A | ENZYME INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1980-09-30 | — | — | US | disclosed |
| EP-0000382-A1 | Pyrimido (4,5-c)pyridazines, compositions containing them and processes for their preparation | THE WELLCOME FOUNDATION LIMITED (GB) | 1979-01-24 | — | — | EP | disclosed |