Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 14/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11224661 | 0.83 | OPRM1 (0.41) | OPRM1SIGMAR1KCNH2DRD2 | |
| SCHEMBL11224414 | 0.82 | SIGMAR1 (0.62) | OPRM1SIGMAR1KCNH2DRD2 | |
| SCHEMBL11235328 | 0.81 | SIGMAR1 (0.45) | OPRM1SIGMAR1KCNH2DRD2 | |
| SCHEMBL11280303 | 0.80 | SIGMAR1 (0.72) | OPRM1SIGMAR1KCNH2 | |
| SCHEMBL11224595 | 0.78 | SIGMAR1 (0.61) | OPRM1SIGMAR1KCNH2DRD2 | |
| SCHEMBL11222563 | 0.78 | SIGMAR1 (0.44) | OPRM1SIGMAR1DRD2 | |
| SCHEMBL11238198 | 0.77 | DRD2 (0.42) | OPRM1DRD2 | |
| SCHEMBL11280305 | 0.76 | SIGMAR1 (0.46) | OPRM1SIGMAR1KCNH2DRD2 | |
| SCHEMBL11220600 | 0.76 | DRD2 (0.46) | OPRM1SIGMAR1KCNH2DRD2 | |
| SCHEMBL11231772 | 0.76 | SIGMAR1 (0.63) | OPRM1SIGMAR1KCNH2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353901-A | HYPERTENSION, CONGESTIVE HEART FAILURE, ARRHYTHMIAMIGRAINE, VASOSPASTIC DISORDERS, ASTHMA | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |