Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | APAF1 | O14727 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11234497 | 0.87 | SLC6A2 (0.33) | LMNAACEKMT2ASMN1; SMN2MME | |
| SCHEMBL11228481 | 0.85 | MAPT (0.32) | ACE | |
| SCHEMBL11228772 | 0.84 | SLC6A2 (0.34) | LMNASMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL11243304 | 0.77 | LMNA (0.37) | LMNASMN1; SMN2SLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7338136 | 0.73 | ACE (0.33) | ACEKMT2AOPRM1 | |
| SCHEMBL11231627 | 0.72 | SLC6A2 (0.31) | LMNAACESLC6A2SLC6A3SLC6A4 | |
| SCHEMBL7347613 | 0.70 | CTSK (0.33) | LMNAACEKMT2ASMN1; SMN2MME | |
| SCHEMBL5889023 | 0.69 | — | — | |
| SCHEMBL28507597 | 0.68 | LMNA (0.36) | LMNASMN1; SMN2CHRM2CHRM1CHRM3 | |
| SCHEMBL7339039 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316905-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |