Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 3/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11224382 | 0.97 | HTR2A (0.37) | MTNR1AHTR2ALMNALRRK2CCR1 | |
| SCHEMBL11231912 | 0.89 | CCR1 (0.34) | CCR1DRD2DRD4KCNH2 | |
| SCHEMBL11224230 | 0.87 | CCR1 (0.42) | CCR1KCNH2 | |
| SCHEMBL11224028 | 0.86 | CCR1 (0.32) | LRRK2CCR1DRD2KCNH2 | |
| SCHEMBL11220558 | 0.86 | DRD2 (0.40) | HTR2ALMNACCR1DRD2DRD4 | |
| SCHEMBL11227376 | 0.85 | CCR1 (0.34) | LRRK2CCR1DRD2DRD4KCNH2 | |
| SCHEMBL11223663 | 0.83 | CCR1 (0.42) | CCR1KCNH2 | |
| SCHEMBL11221152 | 0.82 | MTNR1A (0.48) | MTNR1AHTR2ALRRK2FFAR1DRD2 | |
| SCHEMBL11230978 | 0.78 | MTNR1A (0.44) | MTNR1AHTR2ALRRK2FFAR1DRD2 | |
| SCHEMBL10992228 | 0.75 | SLC6A2 (0.40) | MTNR1ALMNAFFAR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353901-A | HYPERTENSION, CONGESTIVE HEART FAILURE, ARRHYTHMIAMIGRAINE, VASOSPASTIC DISORDERS, ASTHMA | SYNTEX (U.S.A.) INC. (US) | 1982-10-12 | — | — | US | disclosed |