Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11233196 | 0.87 | KDM4E (0.51) | POLBLMNAKDM4EGAAHPGD | |
| SCHEMBL11235309 | 0.82 | ALDH1A1 (0.58) | POLBLMNAKMT2AKDM4EGAA | |
| SCHEMBL11231843 | 0.80 | PDE3B (0.51) | LMNAMEN1KMT2AKDM4EGAA | |
| SCHEMBL28942178 | 0.78 | GAA (0.41) | POLBLMNAKDM4EGAAHPGD | |
| SCHEMBL10854301 | 0.77 | KDM4E (0.59) | POLBMEN1KMT2AKDM4EGAA | |
| SCHEMBL10964419 | 0.77 | KDM4E (0.46) | LMNAMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL11236627 | 0.77 | CCR1 (0.40) | KDM4EGAAHPGDHSD17B10TGFBR1 | |
| SCHEMBL11243686 | 0.77 | KDM4E (0.36) | POLBLMNAMEN1KMT2AKDM4E | |
| SCHEMBL11235898 | 0.76 | KDM4E (0.35) | POLBKDM4EGAACYP1A2DHODH | |
| SCHEMBL11455731 | 0.75 | CCNC (0.35) | POLBLMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |