Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11231843 | 0.81 | PDE3B (0.51) | KDM4ERXFP1KMT2AMEN1LMNA | |
| SCHEMBL11233196 | 0.78 | KDM4E (0.51) | KDM4ERXFP1POLBSMN1; SMN2MAPK1 | |
| SCHEMBL11232009 | 0.78 | KDM4E (0.61) | KDM4ERXFP1KMT2AMEN1LMNA | |
| SCHEMBL11238700 | 0.77 | POLB (0.39) | KDM4ERXFP1POLBKMT2AMEN1 | |
| SCHEMBL11240531 | 0.74 | CA12 (0.39) | KDM4ETP53SMN1; SMN2HTTMAPK1 | |
| SCHEMBL11235309 | 0.73 | ALDH1A1 (0.58) | KDM4EPOLBKMT2ALMNAALDH1A1 | |
| SCHEMBL11235848 | 0.68 | PDE3B (0.67) | KDM4ELMNAHPGDALDH1A1MAPT | |
| SCHEMBL1426158 | 0.67 | GRIN2D (0.45) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29648194 | 0.66 | NOS3 (0.55) | KDM4EPOLBSMN1; SMN2KMT2AMEN1 | |
| SCHEMBL3084862 | 0.66 | NOS3 (0.55) | KDM4EPOLBSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |