Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11248410 | 0.91 | KDM4E (0.58) | KDM4EALDH1A1SMN1; SMN2HTTHPGD | |
| SCHEMBL11241447 | 0.89 | HPGD (0.56) | KDM4EALDH1A1SMN1; SMN2HTTHPGD | |
| Maleic Acid SCHEMBL11245948 | 0.87 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2HPGDLMNA | |
| Maleic Acid SCHEMBL11260650 | 0.83 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2HTTLMNA | |
| Maleic Acid SCHEMBL11264466 | 0.81 | ALDH1A1 (0.43) | KDM4EALDH1A1SMN1; SMN2HTTHPGD | |
| Maleic Acid SCHEMBL11263894 | 0.81 | ALDH1A1 (0.43) | KDM4EALDH1A1SMN1; SMN2HTTHPGD | |
| Maleic Acid SCHEMBL11258141 | 0.81 | KMT2A (0.42) | KDM4EALDH1A1SMN1; SMN2HTTLMNA | |
| Maleic Acid SCHEMBL11253828 | 0.80 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2HTTPKM | |
| Maleic Acid SCHEMBL11250986 | 0.79 | MCL1 (0.50) | KDM4EALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL11151952 | 0.73 | FFAR1 (0.46) | KDM4EALDH1A1SMN1; SMN2HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049060-A1 | Imidazoles | BEECHAM GROUP PLC (GB) | 1982-04-07 | — | — | EP | disclosed |