Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 10/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11264466 | 0.90 | ALDH1A1 (0.43) | MCL1ALDH1A1SMN1; SMN2HTTKDM4E | |
| Maleic Acid SCHEMBL11263894 | 0.90 | ALDH1A1 (0.43) | MCL1ALDH1A1SMN1; SMN2HTTKDM4E | |
| Maleic Acid SCHEMBL11248410 | 0.81 | KDM4E (0.58) | ALDH1A1TP53SMN1; SMN2HTTKDM4E | |
| Maleic Acid SCHEMBL11258141 | 0.80 | KMT2A (0.42) | ALDH1A1SMN1; SMN2HTTKDM4EKMT2A | |
| Maleic Acid SCHEMBL11241428 | 0.79 | KDM4E (0.50) | ALDH1A1SMN1; SMN2HTTKDM4EKMT2A | |
| Maleic Acid SCHEMBL11260650 | 0.78 | ALDH1A1 (0.50) | ALDH1A1GAASMN1; SMN2HTTKDM4E | |
| SCHEMBL11240131 | 0.77 | ALDH1A1 (0.47) | ALDH1A1TP53GAAMAPK1HSD17B10 | |
| Maleic Acid SCHEMBL11250777 | 0.77 | KDM4E (0.48) | MCL1ALDH1A1GAAHTTKDM4E | |
| Maleic Acid SCHEMBL11253828 | 0.74 | KDM4E (0.50) | ALDH1A1SMN1; SMN2HTTKDM4EKMT2A | |
| SCHEMBL11247290 | 0.72 | NPSR1 (0.55) | ALDH1A1SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049060-A1 | Imidazoles | BEECHAM GROUP PLC (GB) | 1982-04-07 | — | — | EP | disclosed |