Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.68 |
| ▸ | DRD3 | P35462 | 5/20 | 0.68 |
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | HTR2A | P28223 | 3/20 | 0.68 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.68 |
| ▸ | HRH1 | P35367 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ESR1 | P03372 | 4/20 | 0.57 |
| ▸ | ESRRG | P62508 | 2/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | ESRRB | O95718 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11240961 | 0.87 | LTA4H (0.74) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL11879949 | 0.83 | HRH1 (0.73) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL29666859 | 0.81 | ALDH1A1 (0.51) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| Phenylpiperazine SCHEMBL11463313 | 0.80 | LTA4H (0.64) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL11249924 | 0.80 | DRD2 (0.60) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL11249919 | 0.80 | DRD2 (0.60) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL29666929 | 0.80 | HRH1 (0.57) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL7464010 | 0.80 | HRH3 (0.69) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL11249917 | 0.80 | DRD2 (0.60) | DRD2DRD3HTR1AHTR2ATMEM97 | |
| SCHEMBL14375117 | 0.79 | THRA (0.69) | DRD2DRD3HTR1AHTR2ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0013546-B1 | PROCESS FOR PRODUCING WOOD/PLASTICS COMPOSITIONS | Österreichisches Forschungszentrum Seibersdorf Ges.m.b.H. (AT) | 1982-05-26 | — | — | EP | claimed |
| US-4336382-A | ADRENERGIC BLOCKING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1982-06-22 | — | — | US | disclosed |
| US-4329289-A | Adrenergic blocking agents | HOFFMANN-LA ROCHE INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4314085-A | Intermediates for preparing adrenergic blocking agents | HOFFMANN-LA ROCHE INC. (US) | 1982-02-02 | — | — | US | disclosed |
| US-4304721-A | Adrenergic blocking agents | HOFFMANN-LA ROCHE INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4301300-A | ADRENERGIC BLOCKING AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1981-11-17 | — | — | US | disclosed |
| US-4285873-A | ANTIANDROGENS | HOFFMANN-LA ROCHE INC. (US) | 1981-08-25 | — | — | US | disclosed |
| US-4281189-A | Sulfonamide intermediates for adrenergic blocking agents | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| US-4278608-A | Adrenergic blocking agents | HOFFMANN-LA ROCHE INC. (US) | 1981-07-14 | — | — | US | disclosed |
| US-4247710-A | THE 3'-HYDROXY, -BENZYLOXY, OR -HALO DERIVATIVES OF METHYL 4-((2'-HYDROXYPROPYL)OXY)PHENYLACETATE | HOFFMANN-LA ROCHE INC. (US) | 1981-01-27 | — | — | US | disclosed |
| US-4202978-A | ADRENERGIC BLOCKING AGENTS, HYPOTENSIVE, ANTISECRETORY, SPASMOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1980-05-13 | — | — | US | disclosed |
| EP-0005142-A1 | Phenylpiperazine derivatives, process for their preparation, intermediates for this purpose and medicaments containing such phenylpiperazine derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1979-11-14 | — | — | EP | disclosed |