Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 12/20 | 0.43 |
| ▸ | MERTK | Q12866 | 12/20 | 0.43 |
| ▸ | FLT3 | P36888 | 10/20 | 0.43 |
| ▸ | GAS6 | Q14393 | 10/20 | 0.43 |
| ▸ | AXL | P30530 | 7/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699118 | 0.79 | TYRO3 (0.51) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL11491617 | 0.77 | CYP1A2 (0.42) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL11239141 | 0.75 | APLNR (0.40) | LMNASMN1; SMN2HSD17B10 | |
| SCHEMBL11232487 | 0.75 | JAK1 (0.46) | SMN1; SMN2HSD17B10 | |
| SCHEMBL11240585 | 0.72 | KDM4E (0.39) | SMN1; SMN2HSD17B10ALOX12 | |
| SCHEMBL29174430 | 0.71 | TYRO3 (0.46) | TYRO3MERTKFLT3GAS6AXL | |
| SCHEMBL11248052 | 0.71 | PDE3B (0.60) | LMNASMN1; SMN2 | |
| SCHEMBL11242781 | 0.71 | CHEK1 (0.47) | LMNASMN1; SMN2 | |
| SCHEMBL7591960 | 0.69 | MMP2 (0.50) | UTS2RLMNATSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL11242290 | 0.69 | CCR1 (0.39) | FLT3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4365065-A | 1-(Pyridinyl)-2-(dimethylamino)ethenyl lower-alkyl ketones | STERLING DRUG INC. (US) | 1982-12-21 | — | — | US | disclosed |
| US-4313951-A | 3-Substituted-6-(lower-alkyl)-5-(pyridinyl)-2(1H)-pyridinones, their cardiotonic use and intermediates therefor | STERLING DRUG INC. (US) | 1982-02-02 | — | — | US | disclosed |