Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30098315 | 1.00 | ALDH1A1 (0.50) | ALDH1A1MAPK1ALOX15LMNARAB9A | |
| Methylene Chloride SCHEMBL28534416 | 0.96 | ALDH1A1 (0.48) | ALDH1A1MAPK1ALOX15LMNARAB9A | |
| SCHEMBL6767819 | 0.84 | AKR1B1 (0.46) | ALDH1A1MAPK1RAB9ACXCL8NPC1 | |
| SCHEMBL1142802 | 0.83 | CES2 (0.45) | ALDH1A1ALOX15CXCL8MEN1KMT2A | |
| SCHEMBL27383077 | 0.83 | ALDH1A1 (0.49) | ALDH1A1MAPK1LMNARAB9ATAAR1 | |
| SCHEMBL1031721 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPK1LMNARAB9ATAAR1 | |
| SCHEMBL29639794 | 0.83 | ALDH1A1 (0.55) | ALDH1A1MAPK1LMNARAB9ATAAR1 | |
| SCHEMBL6969660 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPK1LMNARAB9ATAAR1 | |
| SCHEMBL4661911 | 0.82 | ALDH1A1 (0.51) | ALDH1A1MAPK1LMNARAB9ATAAR1 | |
| SCHEMBL24977211 | 0.82 | ANO1 (0.41) | ALDH1A1MAPK1ALOX15TAAR1CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 192 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107011227-B | Nitrine based on tubulin-beta-lactam Small-molecule probe and its preparation method and application | 郑州大学 | 2019-08-09 | — | — | CN | claimed |
| CN-108191746-A | A kind of novel hydroxyl pyridine compounds and preparation method and application | 暨南大学 | 2018-06-22 | — | — | CN | claimed |
| CN-107011227-A | Nitrine beta-lactam Small-molecule probe based on tubulin and its preparation method and application | 郑州大学 | 2017-08-04 | — | — | CN | claimed |
| CN-104098535-A | Preparation method for 4-(3-fluorine phenyl)-2,2-phenyl-5-(4-(methylmercapto-)phenyl) furan-3(2H)-ketone | NANTONG HUAFENG CHEMICAL CO | 2014-10-15 | — | — | CN | claimed |
| CN-101134739-A | Novel beta-lactam compound and preparation method and chemical uses thereof | CHANGCHUN DISCOVERY SCIENCES L (CN) | 2008-03-05 | — | — | CN | claimed |
| EP-3729190-B1 | ELECTROPHORETIC DISPLAY DEVICE AND ELECTRONIC APPARATUS | E INK CORP (US) | 2024-02-07 | — | — | EP | disclosed |
| EP-3901147-B1 | ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-11-22 | — | — | EP | disclosed |
| CN-109471330-B | Photosensitive composition and photopolymerization initiator used therein | 东京应化工业株式会社 | 2023-08-29 | — | — | CN | disclosed |
| US-20230159538-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2023-05-25 | — | — | US | disclosed |
| US-20230151016-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | GLOBAL BLOOD THERAPEUTICS INC (US) | 2023-05-18 | — | — | US | disclosed |
| EP-4126876-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | Global Blood Therapeutics, Inc. (US) | 2023-02-08 | — | — | EP | disclosed |
| US-11566030-B2 | Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2023-01-31 | — | — | US | disclosed |
| US-4703052-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-10-27 | — | — | US | disclosed |
| EP-0207605-A1 | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1987-01-07 | — | — | EP | disclosed |
| WO-1986007056-A1 | HYPOGLYCEMIC THIAZOLIDINEDIONES | PFIZER INC. (US) | 1986-12-04 | — | — | WO | disclosed |
| US-4473560-A | Diphosphonic acid derivatives and pharmaceutical preparations containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1984-09-25 | — | — | US | disclosed |
| EP-0015690-B1 | PENICILLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM | BEECHAM GROUP PLC (GB) | 1983-04-06 | — | — | EP | disclosed |
| US-4308259-A | Penicillin derivatives | BEECHAM GROUP LIMITED (GB) | 1981-12-29 | — | — | US | disclosed |
| EP-0015690-A1 | Penicillin derivatives, process for their preparation and pharmaceutical composition comprising them | BEECHAM GROUP PLC (GB) | 1980-09-17 | — | — | EP | disclosed |
| US-3992396-A | TRANQUILIZERS, HYPNOTICS | SANDOZ, INC. (US) | 1976-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11566030-B2 | Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators | PDK1, PDK2, PDK3 | ALDH1A1 1703/4885MAPK1 622/4885ALOX15 3911/4885 |
| US-20230151016-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | PDK1, PDK2, PKM | ALDH1A1 1784/4885MAPK1 383/4885ALOX15 3944/4885 |
| US-20230159538-A1 | PYRROLIDINE-PYRAZOLES AS PYRUVATE KINASE ACTIVATORS | PDK1, PDK2, PKM | ALDH1A1 1784/4885MAPK1 383/4885ALOX15 3944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.