Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 14/20 | 0.44 |
| ▸ | ATP4A | P20648 | 4/20 | 0.44 |
| ▸ | ATP4B | P51164 | 4/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.41 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.41 |
| ▸ | DMPK | Q09013 | 1/20 | 0.41 |
| ▸ | MYLK | Q15746 | 1/20 | 0.41 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11244710 | 1.00 | PRMT6 (0.45) | PRMT6ROCK2ROCK1ATP4AATP4B | |
| SCHEMBL3616071 | 0.85 | PRMT6 (0.62) | PRMT6ROCK2ROCK1ATP4AATP4B | |
| SCHEMBL11245292 | 0.84 | MAPT (0.45) | — | |
| SCHEMBL11245298 | 0.84 | MAPT (0.45) | — | |
| SCHEMBL11244719 | 0.81 | ATP4A (0.47) | PRMT6ROCK2ROCK1ATP4AATP4B | |
| SCHEMBL3607745 | 0.81 | ROCK2 (0.56) | ROCK2ROCK1SGK1AKT1GSK3B | |
| Oxalic Acid SCHEMBL11248693 | 0.79 | KDM4E (0.49) | ROCK2ROCK1ATP4AATP4BSGK1 | |
| SCHEMBL11260908 | 0.79 | MAPT (0.42) | ROCK2ROCK1ATP4AATP4B | |
| SCHEMBL11244678 | 0.79 | MAPT (0.42) | ROCK2ROCK1ATP4AATP4B | |
| SCHEMBL11244685 | 0.79 | MAPT (0.42) | ROCK2ROCK1ATP4AATP4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4315009-A | Antisecretory guanidine derivatives and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1982-02-09 | — | — | US | disclosed |
| EP-0003640-B1 | ANTISECRETORY GUANIDINE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-01-27 | — | — | EP | disclosed |
| EP-0003640-A2 | Antisecretory guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-08-22 | — | — | EP | disclosed |