Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDH2 | P40926 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11235287 | 0.90 | HTT (0.70) | MDH2ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL11403307 | 0.84 | GABRA1 (0.56) | MDH2ALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL30467553 | 0.80 | MDH2 (0.62) | MDH2ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL3709669 | 0.80 | ALDH1A1 (0.64) | MDH2ALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL3745105 | 0.76 | MDH2 (0.60) | MDH2ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL2976313 | 0.76 | ALDH1A1 (0.65) | MDH2ALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL10321838 | 0.75 | MDH2 (0.59) | MDH2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4776415 | 0.75 | PRKAB2 (0.63) | MDH2ALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL11273297 | 0.75 | GABRA1 (0.65) | ALDH1A1HPGDHTTMEN1KMT2A | |
| SCHEMBL2010976 | 0.74 | HTT (0.81) | MDH2ALDH1A1HPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0012925-B1 | QUINOLON-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-11-10 | — | — | EP | claimed |
| US-4289777-A | Quinolonecarboxylic acid derivatives and pharmaceutical preparations thereof for treatment of an allergic disease of the respiratory tract | SCHERING, AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | claimed |
| EP-0012925-A1 | Quinolon-carboxylic acid derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-07-09 | — | — | EP | claimed |
| EP-0012925-B1 | QUINOLON-CARBOXYLIC ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-11-10 | — | — | EP | disclosed |
| US-4289777-A | Quinolonecarboxylic acid derivatives and pharmaceutical preparations thereof for treatment of an allergic disease of the respiratory tract | SCHERING, AKTIENGESELLSCHAFT (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0012925-A1 | Quinolon-carboxylic acid derivatives, process for their preparation and pharmaceutical compositions containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1980-07-09 | — | — | EP | disclosed |