Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | RORC | P51449 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 10/20 | 0.48 |
| ▸ | CA2 | P00918 | 10/20 | 0.48 |
| ▸ | CA12 | O43570 | 9/20 | 0.48 |
| ▸ | CA9 | Q16790 | 9/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CA3 | P07451 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.46 |
| ▸ | CA5A | P35218 | 2/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31338871 | 1.00 | LMNA (0.53) | LMNAPOLBRORCHTTALDH1A1 | |
| SCHEMBL31717969 | 0.76 | RORC (0.49) | LMNAPOLBRORCHTTALDH1A1 | |
| Xipamide SCHEMBL29377965 | 0.75 | CA1 (0.48) | LMNAPOLBRORCHTTALDH1A1 | |
| Xipamide SCHEMBL6711167 | 0.75 | CA1 (0.48) | LMNAPOLBRORCHTTALDH1A1 | |
| Xipamide SCHEMBL43532 | 0.75 | CA1 (0.48) | LMNAPOLBRORCHTTALDH1A1 | |
| SCHEMBL17774960 | 0.73 | ALDH1A1 (0.63) | LMNAPOLBRORCHTTALDH1A1 | |
| SCHEMBL31462147 | 0.72 | NPC1 (0.68) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL31606761 | 0.72 | NPC1 (0.68) | LMNAPOLBHTTALDH1A1KDM4E | |
| SCHEMBL4642645 | 0.72 | NPC1 (0.68) | LMNAPOLBHTTALDH1A1KDM4E | |
| Xipamide SCHEMBL6898106 | 0.71 | CA12 (0.48) | POLBRORCCA1CA2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0057763-A1 | Improved process for the preparation of 2-methyl-3-(o-tolyl)-7-chloro-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide | PENNWALT CORPORATION (US) | 1982-08-18 | — | — | EP | claimed |
| EP-0057763-A1 | Improved process for the preparation of 2-methyl-3-(o-tolyl)-7-chloro-1,2,3,4-tetrahydro-4-oxo-6-quinazolinesulfonamide | PENNWALT CORPORATION (US) | 1982-08-18 | — | — | EP | disclosed |
| US-3761480-A | PROCESS FOR THE PREPARATION OF 3-ARYL-6-SULFAMYL-7-HALO-1,2,3,4-TETRAHYDRO-4-QUINAZOLINONES | PENNWALT CORP | 1973-09-25 | — | — | US | disclosed |