Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATP4A | P20648 | 1/20 | 0.44 |
| ▸ | ATP4B | P51164 | 1/20 | 0.44 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 6/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.39 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11238593 | 0.84 | AMY1A (0.43) | MEN1KMT2ASMN1; SMN2ATP4AATP4B | |
| SCHEMBL3601551 | 0.83 | MAPT (0.51) | MEN1KMT2AATMCCR6SMN1; SMN2 | |
| SCHEMBL3597985 | 0.82 | ATP4A (0.61) | ATP4AATP4BPLAU | |
| SCHEMBL3608013 | 0.81 | RAB9A (0.50) | MEN1KMT2ACCR6SMN1; SMN2MAPT | |
| SCHEMBL3602268 | 0.80 | MAPT (0.56) | MEN1KMT2AATMCCR6SMN1; SMN2 | |
| Bromide SCHEMBL11241084 | 0.80 | RAB9A (0.49) | MEN1KMT2ASMN1; SMN2MAPTNPC1 | |
| SCHEMBL3599051 | 0.79 | SMN1; SMN2 (0.46) | MEN1KMT2AATMCCR6SMN1; SMN2 | |
| SCHEMBL3607108 | 0.79 | ABL1 (0.49) | MEN1KMT2ASMN1; SMN2MAPTHSPD1 | |
| SCHEMBL3604799 | 0.77 | ALOX5 (0.61) | MEN1KMT2ASMN1; SMN2ATP4AATP4B | |
| SCHEMBL2393684 | 0.76 | HDAC3 (0.59) | MEN1KMT2ASMN1; SMN2MAPTHSPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003640-B1 | ANTISECRETORY GUANIDINE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-01-27 | — | — | EP | disclosed |