SCHEMBL11249792

SCHEMBL11249792

COC(=O)c1ccc2c(c1)C(=O)OC2

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.53
MEN1 O00255 1/20 0.50
KMT2A Q03164 1/20 0.50
RXFP1 Q9HBX9 1/20 0.50
PPIA P62937 1/20 0.50
CYP3A4 P08684 1/20 0.49
MAPK14 Q16539 2/20 0.47
ALDH1A1 P00352 2/20 0.47
ATM Q13315 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
HSD17B10 Q99714 1/20 0.46
CASP3 P42574 1/20 0.46
GAA P10253 1/20 0.45
HTT P42858 1/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA7 P43166 1/20 0.45
XDH P47989 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3029409 0.88 MAPT (0.55) MAPTCYP3A4ALDH1A1ATMSMN1; SMN2
SCHEMBL11250033 0.84 MAPT (0.69) MAPTMEN1KMT2ARXFP1CYP3A4
SCHEMBL10923685 0.82 MAPK14 (0.58) MAPTKMT2AMAPK14ALDH1A1ATM
SCHEMBL12204908 0.82 MEN1 (0.53) MAPTMEN1KMT2ARXFP1PPIA
SCHEMBL8797606 0.80 ALDH1A1 (0.64) MAPTKMT2AMAPK14ALDH1A1ATM
SCHEMBL6427216 0.80 KMT2A (0.51) MEN1KMT2ARXFP1ALDH1A1CA12
SCHEMBL25517072 0.80 CASP3 (0.44) MAPTMEN1KMT2AMAPK14ALDH1A1
SCHEMBL3853888 0.79 PRF1 (0.55) MAPTMEN1KMT2ARXFP1MAPK14
SCHEMBL30529024 0.78 ROCK2 (0.55) MAPK14ALDH1A1ATMHSD17B10GAA
SCHEMBL20788479 0.78 ROCK2 (0.55) MAPK14ALDH1A1ATMHSD17B10GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4351768-A CARBONLESS, DUPLICATION, INDOLE DYES STERLING DRUG INC. (US) 1982-09-28 US disclosed
US-4322352-A Indolyl phthalide compounds STERLING DRUG INC. (US) 1982-03-30 US disclosed
US-4307018-A CHROMOGENS FOR COPYING SYSTEMS STERLING DRUG INC. (US) 1981-12-22 US disclosed
US-4251446-A COLOR PRECURSORS STERLING DRUG INC. (US) 1981-02-17 US disclosed
US-4189171-A PRESSURE SENSITIVE, THERMAL AND HECTOGRAPHIC SYSTEMS STERLING DRUG INC. (US) 1980-02-19 US disclosed