Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fenmetozole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.48 |
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11161996 | 0.85 | NISCH (0.50) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| SCHEMBL11255915 | 0.83 | NISCH (0.48) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| Fenmetozole SCHEMBL30295426 | 0.83 | NISCH (0.65) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| Fenmetozole SCHEMBL635495 | 0.83 | NISCH (0.65) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| Fenmetozole SCHEMBL635494 | 0.82 | NISCH (0.63) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| Fenmetozole SCHEMBL29913217 | 0.82 | NISCH (0.63) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| SCHEMBL11267562 | 0.81 | NISCH (0.49) | ADRA1ANISCHMAOAMAOBCYP2D6 | |
| SCHEMBL11265808 | 0.77 | NISCH (0.60) | ADRA1ANISCHMAOAMAOBADRA1D | |
| SCHEMBL5201006 | 0.74 | ADRA1A (0.62) | ADRA1ANISCHMAOAMAOBADRA1D | |
| Hydrochloric Acid SCHEMBL5204266 | 0.73 | ADRA1A (0.61) | ADRA1ANISCHMAOAMAOBADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344958-A | BLOOD DISORDERS | THE DOW CHEMICAL COMPANY (US) | 1982-08-17 | — | — | US | disclosed |