Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251330 | 0.85 | SMN1; SMN2 (0.56) | ALDH1A1LMNARAB9AHSD11B1KDM4E | |
| SCHEMBL11347103 | 0.85 | MTNR1A (0.48) | ALDH1A1PTGS2ADORA2BLMNARAB9A | |
| SCHEMBL11251657 | 0.84 | AVPR1A (0.50) | ALDH1A1L3MBTL1LMNAAVPR1AKDM4E | |
| SCHEMBL11240783 | 0.83 | MEN1 (0.56) | ALDH1A1L3MBTL1LMNARAB9AHSD11B1 | |
| SCHEMBL11227630 | 0.80 | AVPR1A (0.49) | AVPR1APARP1ADAM17 | |
| SCHEMBL11235502 | 0.80 | AVPR1A (0.47) | RAB9AAVPR1APARP1 | |
| SCHEMBL11234418 | 0.80 | TPSAB1 (0.46) | HSD11B1AVPR1APARP1 | |
| SCHEMBL11236498 | 0.80 | AVPR1A (0.49) | AVPR1APARP1ADAM17 | |
| SCHEMBL11232216 | 0.79 | AVPR1A (0.51) | HSD11B1AVPR1APARP1 | |
| SCHEMBL11244938 | 0.79 | TPSAB1 (0.55) | ALDH1A1RAB9AAVPR1AHTTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |