Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251330 | 0.93 | SMN1; SMN2 (0.56) | MEN1KMT2AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL11251657 | 0.88 | AVPR1A (0.50) | KMT2AKDM4ESMN1; SMN2MAPTAVPR1A | |
| SCHEMBL11223398 | 0.85 | ADAM17 (0.57) | KMT2AKDM4EMAPTAVPR1AALDH1A1 | |
| SCHEMBL11354265 | 0.84 | ALDH1A1 (0.53) | MEN1KMT2AMAPTAVPR1AALDH1A1 | |
| SCHEMBL11256286 | 0.83 | ALDH1A1 (0.44) | KDM4EAVPR1AALDH1A1L3MBTL1LMNA | |
| SCHEMBL11229177 | 0.82 | TPSAB1 (0.56) | AVPR1AALDH1A1HSD17B10LMNARAB9A | |
| SCHEMBL11230105 | 0.80 | AVPR1A (0.48) | SMN1; SMN2MAPTAVPR1ANPC1RAB9A | |
| SCHEMBL11247565 | 0.80 | ALDH1A1 (0.51) | SMN1; SMN2MAPTAVPR1AALDH1A1NPC1 | |
| SCHEMBL11251234 | 0.80 | AVPR1A (0.49) | SMN1; SMN2GAAMAPTAVPR1AALDH1A1 | |
| SCHEMBL11223947 | 0.80 | AVPR1A (0.62) | AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |