Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11250198 | 0.87 | PARP1 (0.44) | TPSAB1PARP1ESR1ADAMTS5AVPR1A | |
| SCHEMBL11360092 | 0.87 | ADAMTS5 (0.44) | TPSAB1PARP1ALDH1A1HTTESR1 | |
| SCHEMBL11236498 | 0.86 | AVPR1A (0.49) | TPSAB1PARP1ESR1ADAMTS5AVPR1A | |
| SCHEMBL11234418 | 0.86 | TPSAB1 (0.46) | TPSAB1PARP1ESR1ADAMTS5AVPR1A | |
| SCHEMBL11349798 | 0.85 | TPSAB1 (0.47) | TPSAB1PARP1ESR1CTNNB1WNT3A | |
| SCHEMBL11223398 | 0.84 | ADAM17 (0.57) | TPSAB1PARP1ALDH1A1ESR1CTNNB1 | |
| SCHEMBL11352649 | 0.83 | ALDH1A1 (0.51) | TPSAB1PARP1ALDH1A1HPGDNPSR1 | |
| SCHEMBL11235502 | 0.82 | AVPR1A (0.47) | TPSAB1PARP1ESR1ADAMTS5AVPR1A | |
| SCHEMBL11229177 | 0.81 | TPSAB1 (0.56) | TPSAB1PARP1ALDH1A1HTTESR1 | |
| SCHEMBL11227630 | 0.81 | AVPR1A (0.49) | TPSAB1PARP1ESR1ADAMTS5AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007399-B1 | INDOLYLALKYL AMINES, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND PROCESS FOR THEIR MANUFACTURE | MERCK PATENT GmbH (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4251538-A | Indolealkylamines and processes for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-02-17 | — | — | US | disclosed |
| EP-0007399-A1 | Indolylalkyl amines, pharmaceutical preparations containing them and process for their manufacture | MERCK PATENT GmbH (DE) | 1980-02-06 | — | — | EP | disclosed |