Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263009 | 0.85 | PIK3CA (0.35) | TDO2ALDH1A1 | |
| SCHEMBL11260467 | 0.85 | TDO2 (0.42) | TDO2ALDH1A1MAPT | |
| SCHEMBL11260894 | 0.82 | SYK (0.34) | TDO2ALDH1A1MAPTAURKA | |
| SCHEMBL11263420 | 0.79 | HSP90AA1 (0.37) | HSP90AA1PSMB5 | |
| SCHEMBL11252484 | 0.76 | HSP90AA1 (0.35) | TDO2HSP90AA1ALDH1A1AURKAPSMB5 | |
| SCHEMBL11497570 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPT | |
| SCHEMBL13127348 | 0.69 | KDM4E (0.47) | ALDH1A1MAPTAURKA | |
| SCHEMBL11259158 | 0.68 | TDP1 (0.42) | HSP90AA1MAPT | |
| SCHEMBL11439607 | 0.67 | ALDH1A1 (0.47) | ALDH1A1MAPT | |
| SCHEMBL22270629 | 0.65 | APP (0.47) | TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |