Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 3/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | WDR5 | P61964 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 2/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11260467 | 0.87 | TDO2 (0.42) | TDO2ERBB2IDO1KDM4EALDH1A1 | |
| SCHEMBL11260894 | 0.85 | SYK (0.34) | TDO2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11260164 | 0.85 | TDO2 (0.33) | TDO2ALDH1A1 | |
| SCHEMBL11259590 | 0.78 | TRPV1 (0.37) | PIK3CAPIK3CBPIK3CGPIP4K2AALDH1A1 | |
| SCHEMBL11253329 | 0.74 | TRPV1 (0.44) | PIK3CAPIK3CGTDO2IDO1KDM4E | |
| SCHEMBL11261674 | 0.73 | TDO2 (0.36) | TDO2PIP4K2AADORA2AADORA1ERBB2 | |
| SCHEMBL11267833 | 0.73 | PIP4K2A (0.38) | PIP4K2AALDH1A1TRPV1 | |
| SCHEMBL11256693 | 0.72 | ALDH1A1 (0.39) | TDO2IDO1KDM4EALDH1A1HPGD | |
| SCHEMBL11497570 | 0.72 | ALDH1A1 (0.40) | ADORA2AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL11258335 | 0.69 | ALDH1A1 (0.39) | TDO2IDO1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |