Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 8/20 | 0.58 |
| ▸ | HTR1A | P08908 | 6/20 | 0.58 |
| ▸ | DRD1 | P21728 | 5/20 | 0.58 |
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | HTR7 | P34969 | 3/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | DRD5 | P21918 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11281497 | 0.97 | DRD3 (0.57) | DRD3HTR1ADRD1DRD2HTR2A | |
| SCHEMBL5101030 | 0.85 | HRH3 (0.56) | DRD3HTR1ADRD1DRD2HTR2A | |
| SCHEMBL11279326 | 0.84 | HTR1A (0.63) | DRD3HTR1ADRD2HTR2AHRH1 | |
| SCHEMBL11809668 | 0.81 | HTR1A (0.63) | DRD3HTR1ADRD2HTR2AHRH1 | |
| SCHEMBL11273380 | 0.81 | FAAH (0.56) | DRD3HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL11270870 | 0.81 | HTR1A (0.59) | DRD3HTR1ADRD2HTR2AHRH1 | |
| SCHEMBL9795963 | 0.80 | HRH3 (0.47) | DRD3HTR1ADRD2HTR2A | |
| SCHEMBL11277272 | 0.80 | HTR2A (0.67) | DRD3HTR1ADRD1DRD2HTR2A | |
| SCHEMBL11272267 | 0.80 | HTR2A (0.50) | DRD3HTR1ADRD2HTR2AHTR7 | |
| SCHEMBL11273977 | 0.80 | HTR1A (0.56) | DRD3HTR1ADRD1DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |