Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11277127 | 0.80 | TSHR (0.35) | LMNASMN1; SMN2KDM4EMAPTKMT2A | |
| SCHEMBL11261713 | 0.78 | CRBN (0.36) | LMNACRBNKDM4EMAPTKMT2A | |
| SCHEMBL11257799 | 0.72 | KMT2A (0.38) | LMNACRBNKDM4EMAPTKMT2A | |
| SCHEMBL11269817 | 0.72 | CRBN (0.39) | LMNACRBNKDM4EMAPTKMT2A | |
| SCHEMBL11264137 | 0.72 | — | — | |
| SCHEMBL11274787 | 0.72 | CRBN (0.39) | LMNACRBNKDM4EMAPTKMT2A | |
| SCHEMBL11261370 | 0.72 | MTNR1A (0.41) | LMNAMAPTKMT2A | |
| SCHEMBL11270278 | 0.71 | LMNA (0.38) | LMNACRBNKDM4EMAPTKMT2A | |
| SCHEMBL11268058 | 0.69 | ALDH1A1 (0.33) | LMNACRBN | |
| SCHEMBL11267205 | 0.69 | MAPT (0.43) | LMNASMN1; SMN2KDM4EMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329363-A | Substituted mercapto acid amides and their use | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4216160-A | IMMUNOREGULANTS FOR CORRECTING AN INBALANCE OF IMMUNE HOMEOSTASIS | MERCK & CO., INC. (US) | 1980-08-05 | — | — | US | disclosed |
| EP-0001989-A1 | Substituted mercapto acid amides, process for their preparation, pharmaceutical composition containing same and their use | MERCK & CO. INC. (US) | 1979-05-30 | — | — | EP | disclosed |