Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264480 | 0.76 | KMT2A (0.60) | MTNR1AMTNR1BALDH1A1KMT2APOLB | |
| SCHEMBL11259579 | 0.73 | PAM (0.62) | ALDH1A1KMT2AL3MBTL1ATMTDP1 | |
| SCHEMBL11264044 | 0.72 | LMNA (0.41) | KMT2AMAPTLMNA | |
| SCHEMBL11269396 | 0.71 | LMNA (0.57) | MTNR1AMTNR1BALDH1A1KMT2ANPC1 | |
| SCHEMBL11267948 | 0.71 | MAPT (0.51) | ALDH1A1KMT2ANPC1POLBHTT | |
| SCHEMBL11266403 | 0.70 | CYP1A2 (0.43) | ALDH1A1KMT2APOLBHTTMAPT | |
| SCHEMBL11264131 | 0.70 | TDP1 (0.49) | ALDH1A1KMT2ANPC1POLBHTT | |
| SCHEMBL11270801 | 0.70 | TDP1 (0.49) | ALDH1A1KMT2ANPC1POLBHTT | |
| SCHEMBL10866960 | 0.69 | EPHX1 (0.50) | MTNR1AMTNR1BNPSR1ALDH1A1KMT2A | |
| SCHEMBL11277127 | 0.69 | TSHR (0.35) | ALDH1A1KMT2AHTTMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4329363-A | Substituted mercapto acid amides and their use | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |
| US-4216160-A | IMMUNOREGULANTS FOR CORRECTING AN INBALANCE OF IMMUNE HOMEOSTASIS | MERCK & CO., INC. (US) | 1980-08-05 | — | — | US | disclosed |
| EP-0001989-A1 | Substituted mercapto acid amides, process for their preparation, pharmaceutical composition containing same and their use | MERCK & CO. INC. (US) | 1979-05-30 | — | — | EP | disclosed |