Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.42 |
| ▸ | TOP1 | P11387 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14868432 | 0.84 | SNCA (0.37) | PYGLALOX15ERCC1ERCC4SNCA | |
| SCHEMBL11269107 | 0.84 | TOP1 (0.36) | PYGLSNCATOP1ALDH1A1APEX1 | |
| SCHEMBL11280533 | 0.79 | PYGL (0.47) | PYGLALOX15ERCC1ERCC4SNCA | |
| SCHEMBL11275768 | 0.79 | PYGL (0.49) | PYGLALOX15ERCC1ERCC4SNCA | |
| SCHEMBL109020 | 0.77 | ALOX15 (0.66) | PYGLALOX15ERCC1ERCC4SNCA | |
| SCHEMBL13804531 | 0.74 | ALDH1A1 (0.55) | PYGLALOX15ERCC1ERCC4SNCA | |
| SCHEMBL10855224 | 0.74 | MDM2 (0.58) | BCHEALDH1A1MEN1KMT2APKM | |
| SCHEMBL11276328 | 0.74 | SNCA (0.41) | ALOX15ERCC1ERCC4SNCATOP1 | |
| SCHEMBL11277145 | 0.72 | SNCA (0.42) | ALOX15ERCC1ERCC4SNCATOP1 | |
| SCHEMBL18155290 | 0.71 | ALOX15 (0.55) | PYGLALOX15ERCC1ERCC4SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |