Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 2/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | POLH | Q9Y253 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PLAT | P00750 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280226 | 0.82 | TOP1 (0.39) | PYGLSNCATOP1PLAU | |
| SCHEMBL14868391 | 0.82 | SNCA (0.40) | PYGLALOX15SNCATOP1ERCC1 | |
| SCHEMBL11596366 | 0.81 | SNCA (0.44) | PYGLALOX15SNCATOP1ERCC1 | |
| SCHEMBL109020 | 0.81 | ALOX15 (0.66) | PYGLALOX15SNCATOP1ERCC1 | |
| SCHEMBL11280533 | 0.80 | PYGL (0.47) | PYGLALOX15SNCATOP1ERCC1 | |
| Hydrochloric Acid SCHEMBL11594293 | 0.80 | SNCA (0.43) | PYGLALOX15SNCATOP1ERCC1 | |
| SCHEMBL11133331 | 0.79 | ALOX15 (0.47) | ALOX15SNCATOP1ERCC1ERCC4 | |
| SCHEMBL6692568 | 0.79 | SNCA (0.49) | PYGLALOX15SNCATOP1ERCC1 | |
| SCHEMBL11265563 | 0.79 | PYGL (0.46) | PYGLALOX15SNCATOP1ERCC1 | |
| SCHEMBL9673117 | 0.78 | ALOX15 (0.54) | PYGLALOX15SNCATOP1ERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |