Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.68 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.68 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.63 |
| ▸ | HRH1 | P35367 | 2/20 | 0.63 |
| ▸ | DRD2 | P14416 | 5/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11268962 | 0.96 | ADRA1A (0.67) | ADRA1AADRA1DADRA1BMAPTTDP1 | |
| SCHEMBL11278148 | 0.90 | KCNH2 (0.64) | ADRA1AADRA1DADRA1BHRH3HRH1 | |
| SCHEMBL11274382 | 0.89 | DRD2 (0.62) | ADRA1AADRA1DADRA1BMAPTTDP1 | |
| SCHEMBL11271331 | 0.89 | HRH3 (0.61) | ADRA1AADRA1DADRA1BMAPTTDP1 | |
| SCHEMBL11269168 | 0.88 | ADRA1D (0.68) | ADRA1AADRA1DADRA1BHRH3HRH1 | |
| SCHEMBL11276891 | 0.88 | HTR7 (0.66) | ADRA1AADRA1DADRA1BHRH3HRH1 | |
| SCHEMBL11219235 | 0.88 | HRH1 (0.80) | ADRA1AMAPTTDP1HRH3HRH1 | |
| Hydrochloric Acid SCHEMBL11273968 | 0.87 | HRH1 (0.78) | ADRA1AMAPTTDP1HRH3HRH1 | |
| SCHEMBL11282931 | 0.86 | HRH3 (0.67) | HRH3HRH1 | |
| SCHEMBL11284279 | 0.85 | HRH3 (0.59) | ADRA1AADRA1DADRA1BMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |