Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 3/20 | 0.74 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.74 |
| ▸ | DRD2 | P14416 | 4/20 | 0.65 |
| ▸ | DRD3 | P35462 | 3/20 | 0.64 |
| ▸ | HTR7 | P34969 | 2/20 | 0.64 |
| ▸ | HTR1A | P08908 | 3/20 | 0.61 |
| ▸ | HTR2A | P28223 | 3/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11219235 | 0.96 | HRH1 (0.80) | HRH1HRH3DRD2DRD3HTR7 | |
| Hydrochloric Acid SCHEMBL11273968 | 0.95 | HRH1 (0.78) | HRH1HRH3DRD2DRD3HTR7 | |
| SCHEMBL11285664 | 0.88 | HTR7 (0.65) | HRH1HRH3DRD2DRD3HTR7 | |
| SCHEMBL11277312 | 0.88 | SLC6A2 (0.68) | HRH1HRH3DRD2DRD3HTR1A | |
| SCHEMBL11268962 | 0.88 | ADRA1A (0.67) | HRH1HRH3DRD2DRD3HTR7 | |
| SCHEMBL11278328 | 0.88 | HRH1 (0.58) | HRH1HRH3DRD2DRD3HTR7 | |
| SCHEMBL11278975 | 0.88 | ADRA1D (0.68) | HRH1HRH3DRD2HTR7SLC6A2 | |
| SCHEMBL6685654 | 0.85 | HRH3 (1.00) | HRH1HRH3DRD3KCNH2 | |
| SCHEMBL11278314 | 0.85 | SLC6A4 (0.70) | HRH1HRH3DRD2DRD3HTR7 | |
| SCHEMBL11285131 | 0.85 | DRD2 (0.69) | HRH1HRH3DRD2HTR7HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4339580-A | TRANQUILIZERS, SEDATIVES | MITSUBISHI CHEMICAL INDUSTRIES, LIMITED (JP) | 1982-07-13 | — | — | US | disclosed |
| EP-0021368-B1 | PIPERAZINYLALKOXYINDANES AND ACID ADDITION SALTS THEREOF | MITSUBISHI KASEI CORPORATION (JP) | 1982-05-19 | — | — | EP | disclosed |
| EP-0021368-A1 | Piperazinylalkoxyindanes and acid addition salts thereof | MITSUBISHI KASEI CORPORATION (JP) | 1981-01-07 | — | — | EP | disclosed |