Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.39 |
| ▸ | MMP3 | P08254 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11259867 | 0.92 | ALDH1A1 (0.45) | CCR5ALDH1A1HTTKDM4EPOLB | |
| SCHEMBL11403843 | 0.89 | FDFT1 (0.40) | CCR5ALDH1A1HTTPOLB | |
| SCHEMBL11270328 | 0.85 | POLB (0.47) | CCR5SMN1; SMN2CMA1POLBMMP1 | |
| SCHEMBL11261726 | 0.85 | LMNA (0.42) | CCR5ALDH1A1HTTSMN1; SMN2POLB | |
| SCHEMBL8726366 | 0.78 | PLA2G10 (0.56) | ALDH1A1POLBMMP1MMP3MMP9 | |
| SCHEMBL11263500 | 0.78 | MAPK1 (0.50) | ALDH1A1HTTKDM4ESMN1; SMN2 | |
| SCHEMBL11262289 | 0.77 | CYP3A4 (0.43) | KDM4E | |
| SCHEMBL11260879 | 0.76 | MMP1 (0.41) | HTTSMN1; SMN2MMP1MMP3MMP9 | |
| SCHEMBL5670141 | 0.74 | HRH3 (0.49) | CCR5ALDH1A1HTTKDM4EPOLB | |
| SCHEMBL11262980 | 0.73 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2POLBMMP1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005647-B1 | HYDANTOIN COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | Lilly Industries Limited (GB) | 1982-06-09 | — | — | EP | disclosed |
| US-4293563-A | ANTIASTHMATICS | LILLY INDUSTRIES LIMITED (GB) | 1981-10-06 | — | — | US | disclosed |
| US-4241073-A | ASTHMA | LILLY INDUSTRIES LIMITED (GB) | 1980-12-23 | — | — | US | disclosed |
| EP-0005647-A1 | Hydantoin compounds, their preparation and pharmaceutical formulations containing them | Lilly Industries Limited (GB) | 1979-11-28 | — | — | EP | disclosed |