Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5672105 | 0.90 | HRH3 (0.50) | HRH3KDM4EALDH1A1HTTPOLB | |
| SCHEMBL5670771 | 0.89 | HRH3 (0.43) | HRH3KDM4EALDH1A1HTTPOLB | |
| SCHEMBL11259867 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1HTTPOLBCCR5 | |
| SCHEMBL5671995 | 0.81 | HRH3 (0.63) | HRH3KDM4EALDH1A1HTTLTA4H | |
| SCHEMBL11267710 | 0.74 | CCR5 (0.47) | KDM4EALDH1A1HTTPOLBCCR5 | |
| SCHEMBL5672391 | 0.73 | KDM4E (0.49) | HRH3KDM4EALDH1A1HTTHPGD | |
| SCHEMBL11403843 | 0.72 | FDFT1 (0.40) | ALDH1A1HTTPOLBCCR5HPGD | |
| SCHEMBL6496864 | 0.71 | ALDH1A1 (0.73) | HRH3KDM4EALDH1A1HTTHPGD | |
| SCHEMBL11261726 | 0.70 | LMNA (0.42) | ALDH1A1HTTPOLBCCR5LTA4H | |
| SCHEMBL6499571 | 0.69 | ALDH1A1 (0.75) | KDM4EALDH1A1HTTHPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542686-A4 | ARYL SUBSTITUTED HYDANTOIN COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS | EURO CELTIQUE SA (LU) | 2006-10-18 | — | — | EP | claimed |
| EP-1542686-A2 | ARYL SUBSTITUTED HYDANTOIN COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS | Euro-Celtique S.A. (LU) | 2005-06-22 | — | — | EP | claimed |
| WO-2004010950-A2 | ARYL SUBSTITUTED HYDANTOIN COMPOUNDS AND THEIR USE AS SODIUM CHANNEL BLOCKERS | EURO-CELTIQUE S.A. (LU) | 2004-02-05 | — | — | WO | claimed |