Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 5/20 | 0.33 |
| ▸ | AKT2 | P31751 | 2/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TYMP | P19971 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11470743 | 0.71 | POLB (0.44) | LMNAALDH1A1RAB9AHPGDTP53 | |
| SCHEMBL2374537 | 0.67 | AKT2 (0.37) | LMNAALDH1A1RENAKT2CHEK1 | |
| SCHEMBL4606866 | 0.64 | ESR1 (0.55) | ALDH1A1HPGDKMT2A | |
| SCHEMBL2376564 | 0.64 | AKT1 (0.51) | LMNAAKT2KMT2A | |
| SCHEMBL9458893 | 0.62 | HSD17B10 (0.47) | LMNAALDH1A1PDGFRAMAPK8CDK5 | |
| SCHEMBL1127247 | 0.62 | HTT (0.48) | ALDH1A1AKT2CHEK1CDK5HPGD | |
| SCHEMBL11103639 | 0.62 | KCNH2 (0.48) | LMNA | |
| Biphenyl SCHEMBL4856272 | 0.61 | ALDH1A1 (0.50) | LMNAALDH1A1PDE4BHPGDCA2 | |
| SCHEMBL26907879 | 0.61 | MMP12 (0.38) | LMNAKMT2A | |
| SCHEMBL28025320 | 0.60 | ADRB2 (0.39) | LMNAALDH1A1CHEK1CDK5HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |