Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 2/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | PRKCG | P05129 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5951254 | 0.84 | TDO2 (0.39) | DYRK1AHTTALDH1A1HPGD | |
| SCHEMBL29504118 | 0.79 | AXL (0.39) | ADRB2CDC7PLK4CHEK1CHUK | |
| SCHEMBL28992468 | 0.79 | DHFR (0.44) | CDC7PLK4CHEK1CHUKPDPK1 | |
| SCHEMBL11410819 | 0.75 | GP6 (0.49) | KDM4EMAPK1L3MBTL1HTTGAA | |
| SCHEMBL10612540 | 0.75 | LMNA (0.45) | KDM4EL3MBTL1HTTGAATSHR | |
| SCHEMBL20524398 | 0.74 | HCAR2 (0.39) | HCAR2 | |
| SCHEMBL28025288 | 0.73 | ALOX15 (0.38) | KDM4EMAPK1GAAALDH1A1LMNA | |
| SCHEMBL31263880 | 0.73 | KCNH3 (0.43) | HCAR2MAPK1HTTGAAALDH1A1 | |
| SCHEMBL5139872 | 0.71 | HPGD (0.36) | ADRB2KDM4ECDC7PLK4CHEK1 | |
| SCHEMBL27556128 | 0.71 | TSHR (0.46) | MAPK1L3MBTL1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102292321-B | Pyrazolyl-substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor for the treatment of receptor-related disorders | ARENA PHARMACEUTICALS, INC. (US) | 2015-08-12 | — | — | CN | disclosed |