Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11569274 | 0.87 | ALDH1A1 (0.49) | OXTRAVPR1AMEN1KMT2AALDH1A1 | |
| SCHEMBL7089167 | 0.83 | PKM (0.52) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL9681343 | 0.81 | HDAC3 (0.44) | MEN1KMT2AALDH1A1POLBCISD1 | |
| SCHEMBL30643863 | 0.80 | LOXL2 (0.45) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL20919482 | 0.80 | LOXL2 (0.45) | ALDH1A1CYP1A2CYP2D6CYP2C19MAPT | |
| SCHEMBL14847556 | 0.77 | MAPT (0.43) | MEN1KMT2AALDH1A1POLBMAPT | |
| SCHEMBL20715674 | 0.77 | HDAC8 (0.42) | MEN1KMT2APOLBCYP1A2CYP2C19 | |
| SCHEMBL13559770 | 0.77 | POLB (0.51) | MEN1KMT2AALDH1A1POLBCYP1A2 | |
| SCHEMBL11964451 | 0.77 | HDAC3 (0.49) | ALDH1A1SMN1; SMN2GAALMNAL3MBTL1 | |
| SCHEMBL9134263 | 0.76 | HDAC1 (0.49) | MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0005318-B1 | N-HETEROCYCLYL-4-PIPERIDINAMINES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, INTERMEDIATES THEREFOR, AND METHOD FOR THE PREPARATION OF THE INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-01-06 | — | — | EP | disclosed |