Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9681992 | 0.87 | HDAC8 (0.42) | HDAC8MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL1519151 | 0.83 | SMN1; SMN2 (0.47) | HDAC8MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL9682901 | 0.81 | MAPT (0.43) | HDAC8MEN1KMT2ARAB9AMAPT | |
| SCHEMBL13559770 | 0.81 | POLB (0.51) | HDAC8MEN1KMT2ACYP1A2CYP2C9 | |
| SCHEMBL15824736 | 0.80 | MEN1 (0.59) | MEN1KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL16042274 | 0.78 | GHSR (0.47) | MAPT | |
| SCHEMBL14847556 | 0.77 | MAPT (0.43) | MEN1KMT2AMAPTL3MBTL1EGFR | |
| SCHEMBL13332614 | 0.77 | KMT2A (0.51) | MEN1KMT2ARAB9AMAPTL3MBTL1 | |
| SCHEMBL11268602 | 0.77 | OXTR (0.49) | MEN1KMT2ACYP1A2CYP2C19RAB9A | |
| SCHEMBL13186988 | 0.77 | ACP1 (0.49) | HDAC8MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028308-A1 | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES, AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2019-02-07 | — | — | WO | disclosed |