Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30643863 | 1.00 | LOXL2 (0.45) | LOXL2AKR1B1HRH4MAOAMAOB | |
| SCHEMBL11268602 | 0.80 | OXTR (0.49) | MAOAMAOBALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7089167 | 0.80 | PKM (0.52) | KDM4EALDH1A1HPGDMAPTL3MBTL1 | |
| SCHEMBL15540453 | 0.79 | CD38 (0.42) | IDH1CD38 | |
| SCHEMBL16489549 | 0.79 | HSD17B10 (0.53) | KDM4EALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL22481555 | 0.78 | KDM4E (0.51) | LOXL2MAOAMAOBKDM4EALDH1A1 | |
| SCHEMBL20919464 | 0.77 | MAPT (0.58) | CYP1A2CYP2C9HPGDCYP2C19MAPT | |
| SCHEMBL6396768 | 0.76 | LOXL2 (0.59) | LOXL2AKR1B1MAOAMAOBKDM4E | |
| SCHEMBL5992840 | 0.74 | MEN1 (0.56) | LOXL2MAOAMAOBCYP1A2CYP2C9 | |
| SCHEMBL30643883 | 0.74 | IDH1 (0.42) | KDM4EALDH1A1HPGDIDH1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3697410-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | TEIJIN PHARMA LTD (JP) | 2024-12-18 | — | — | EP | disclosed |
| CN-111417394-B | Benzimidazole derivatives and uses thereof | 帝人制药株式会社 | 2023-11-07 | — | — | CN | disclosed |
| US-11332459-B2 | Benzimidazole derivatives and their uses | TEIJIN PHARMA LIMITED (JP) | 2022-05-17 | — | — | US | disclosed |
| US-11332459-B2 | Benzimidazole derivatives and their uses | TEIJIN PHARMA LIMITED (JP) | 2022-05-17 | — | — | US | disclosed |
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2020-10-01 | — | — | US | disclosed |
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2020-10-01 | — | — | US | disclosed |
| EP-3697410-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | Amgen Inc. (US) | 2020-08-26 | — | — | EP | disclosed |
| CN-111417394-A | Benzimidazole derivatives and uses thereof | 安进公司 | 2020-07-14 | — | — | CN | disclosed |
| WO-2019079578-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | AMGEN INC. (US) | 2019-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200308145-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USES | TRPC6, TRPV6, TRPM6 | LOXL2 4590/4885AKR1B1 2205/4885HRH4 292/4885 |
| US-11332459-B2 | Benzimidazole derivatives and their uses | TRPC6, TRPV6, TRPM6 | LOXL2 4590/4885AKR1B1 2205/4885HRH4 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.