SCHEMBL11269403

SCHEMBL11269403

Cc1[c]ccc(-c2ccccc2)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.42
CD274 Q9NZQ7 1/20 0.42
CYP2A6 P11509 2/20 0.38
CYP2B6 P20813 1/20 0.38
AKT1 P31749 1/20 0.35
AKT2 P31751 1/20 0.35
ESR2 Q92731 1/20 0.35
PARP10 Q53GL7 1/20 0.35
PARP11 Q9NR21 1/20 0.35
BACE1 P56817 1/20 0.34
SQOR Q9Y6N5 1/20 0.34
ALDH1A1 P00352 5/20 0.33
HSD17B10 Q99714 3/20 0.33
HPGD P15428 2/20 0.33
BCL2L1 Q07817 1/20 0.33
MAPK1 P28482 1/20 0.33
PTGS1 P23219 1/20 0.33
KDM4E B2RXH2 1/20 0.32
PTGS2 P35354 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8465845 0.83 ACHE (0.35) PTGS1PTGS2ACHE
SCHEMBL6829533 0.81 CYP2A6 (0.36) PDCD1CD274CYP2A6CYP2B6AKT1
SCHEMBL7461959 0.79 CYP2A6 (0.35) PDCD1CD274CYP2A6CYP2B6AKT1
SCHEMBL8210178 0.79 HDAC4 (0.44) PDCD1CD274CYP2A6CYP2B6AKT1
SCHEMBL7469723 0.79 CYP2A6 (0.40) PDCD1CD274CYP2A6CYP2B6AKT1
SCHEMBL1996693 0.77 ACHE (0.39) ESR2HTR7PDE3BPDE3AACHE
SCHEMBL28990346 0.76 TSHR (0.40) ALDH1A1HSD17B10HPGDKDM4EADRA1A
SCHEMBL6991078 0.76 SQOR (0.41) PDCD1CD274CYP2A6CYP2B6PARP10
SCHEMBL695988 0.76 PDCD1 (0.39) PDCD1CD274CYP2A6CYP2B6AKT1
SCHEMBL9412187 0.74 PDCD1 (0.38) PDCD1CD274CYP2A6CYP2B6AKT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102361640-B Isoxazole pyridone is in the purposes prepared in the medicine of the symptom alleviating or alleviating warm-blooded mammals arthritis and asthma 范安德尔研究所 2016-10-19 CN claimed
CN-102361640-A Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids VAN ANDEL RES INST 2012-02-22 CN claimed
WO-2019189037-A1 FUSED-RING COMPOUND, METHOD FOR PRODUCING SAME, AND PRODUCTION INTERMEDIATE THEREOF 東ソー株式会社 2019-10-03 WO disclosed
US-8937195-B2 Method for producing the transition metal complex, catalyst for trimerization, method for producing 1-hexene, method for producing the substituted cyclopentadiene compound (1) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-01-20 US disclosed
EP-2691406-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (1) Sumitomo Chemical Company, Limited (JP) 2014-02-05 EP disclosed
US-20140018564-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (1) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2014-01-16 US disclosed
WO-2012133924-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (1) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed
WO-2012133935-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (3) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed
CN-102361640-A Methods of using substituted isoxazolo pyridinones as dissociated glucocorticoids VAN ANDEL RES INST 2012-02-22 CN disclosed
US-4325951-A 1-Oxadethiacephalosporin derivatives and antibacterial use thereof MEIJI SEIKA KAISHA, LTD. (JP) 1982-04-20 US disclosed