SCHEMBL8465845

SCHEMBL8465845

Cc1ccc(-c2cc[c]c(C)c2C)cc1

nearest known ligand 0.35

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
PTGS2 P35354 3/20 0.32
MEN1 O00255 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
KMT2A Q03164 1/20 0.30
PTGS1 P23219 1/20 0.30
ADORA3 P0DMS8 1/20 0.30
MAOB P27338 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11269403 0.83 PDCD1 (0.42) ACHEPTGS2PTGS1
SCHEMBL28990346 0.80 TSHR (0.40) TDP1NPC1RAB9A
SCHEMBL8819823 0.78 PTGS2 (0.36) TDP1PTGS2NPC1PTGS1
SCHEMBL4280005 0.76 HPGDS (0.40) PTGS2NPC1RAB9APTGS1
SCHEMBL2565144 0.74 TDP1 (0.35) ACHETDP1MEN1NPC1RAB9A
SCHEMBL15453986 0.74 ALDH1A1 (0.34) TDP1MEN1RAB9AKMT2AMAOB
SCHEMBL446052 0.74 MAPT (0.37) TDP1MEN1NPC1RAB9AKMT2A
SCHEMBL4285266 0.71 HSD17B1 (0.40) PTGS2PTGS1
SCHEMBL16344216 0.71 RAB9A (0.37) ACHEMEN1NPC1RAB9AKMT2A
SCHEMBL2834322 0.71 PTGS2 (0.35) ACHETDP1PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10640641-B2 Curable coating compositions of silane functional polymers KING INDUSTRIES (US) 2020-05-05 US disclosed
US-20200062953-A1 CURABLE COATING COMPOSITIONS OF SILANE FUNCTIONAL POLYMERS KING INDUSTRIES 2020-02-27 US disclosed
US-10167303-B2 Iridium organometallic complex containing a substituted dibenzo[f,h]quinoxaline and an electronic device having an emitting layer containing the iridium complex UDC IRELAND LIMITED (IE) 2019-01-01 US disclosed
US-20180237635-A1 CURABLE COATING COMPOSITIONS OF SILANE FUNCTIONAL POLYMERS KING INDUSTRIES 2018-08-23 US disclosed
US-9976028-B2 Curable coating compositions of silane functional polymers KING INDUSTRIES (US) 2018-05-22 US disclosed
WO-2016137881-A1 CURABLE COATING COMPOSITIONS OF SILANE FUNCTIONAL POLYMERS KING INDUSTRIES (US) 2016-09-01 WO disclosed
US-20160244606-A1 CURABLE COATING COMPOSITIONS OF SILANE FUNCTIONAL POLYMERS KING INDUSTRIES 2016-08-25 US disclosed
US-8912113-B2 Compositions of a metal amidine complex and second compound, coating compositions comprising same KING INDUSTRIES, INC. (US) 2014-12-16 US disclosed
EP-2683767-A1 COMPOSITIONS OF A METAL AMIDINE COMPLEX AND SECOND COMPOUND, COATING COMPOSITIONS COMPRISING SAME KING INDUSTRIES, INC. (US) 2014-01-15 EP disclosed
WO-2012122098-A1 COMPOSITIONS OF A METAL AMIDINE COMPLEX AND SECOND COMPOUND, COATING COMPOSITIONS COMPRISING SAME KING INDUSTRIES, INC. (US) 2012-09-13 WO disclosed
US-20120225982-A1 COMPOSITIONS OF A METAL AMIDINE COMPLEX AND SECOND COMPOUND, COATING COMPOSITIONS COMPRISING SAME KING INDUSTRIES, INC. 2012-09-06 US disclosed
US-5879436-A REACTION PRODUCT OF CARBOXYLIC ACID AND AMINOSILANE; PROTECTIVE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1999-03-09 US disclosed
US-5153306-A AROMATIC POLYETHERS, FLUORESCENT RESIN COMPOSITIONS CONTAINING SAME, AND PROCESSES FOR PREPARING SAME IDEMITSU KOSAN COMPANY LIMITED (JP) 1992-10-06 US disclosed
EP-0164850-B1 A NOVEL PROCESS FOR THE PREPARATION OF OXAZOLINES ELI LILLY AND COMPANY (US) 1989-03-22 EP disclosed
US-4587053-A Preparation of oxazolines ELI LILLY AND COMPANY (US) 1986-05-06 US disclosed
EP-0164850-A1 A novel process for the preparation of oxazolines ELI LILLY AND COMPANY (US) 1985-12-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10167303-B2 Iridium organometallic complex containing a substituted dibenzo[f,h]quinoxaline and an electronic device having an emitting layer containing the iridium complex NDUFS5, DDT, NDUFV2 ACHE 330/4885TDP1 2226/4885PTGS2 3322/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.