Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127046 | 0.86 | CNR1 (0.46) | GFERKDM4EALDH1A1MAPK1CNR1 | |
| SCHEMBL15162305 | 0.84 | KDM4E (0.46) | KDM4EALDH1A1MAPK1CNR2SMN1; SMN2 | |
| SCHEMBL1127023 | 0.79 | ALDH1A1 (0.58) | KDM4EALDH1A1SMN1; SMN2CYP2C19KMT2A | |
| SCHEMBL1126911 | 0.78 | HTR2C (0.41) | KDM4EALDH1A1MAPK1CNR2SMN1; SMN2 | |
| SCHEMBL15162449 | 0.75 | ALDH1A1 (0.42) | KDM4EALDH1A1MAPK1CNR1CNR2 | |
| SCHEMBL15162319 | 0.74 | THRB (0.36) | GFERKDM4EALDH1A1THRBSMN1; SMN2 | |
| SCHEMBL1126989 | 0.74 | ALDH1A1 (0.39) | ALDH1A1CNR1CNR2CYP1A2CYP3A4 | |
| SCHEMBL1988726 | 0.72 | CCNC (0.40) | GFERKDM4EALDH1A1MAPK1CNR1 | |
| SCHEMBL1126908 | 0.71 | ALDH1A1 (0.38) | KDM4EALDH1A1CNR1CNR2KMT2A | |
| SCHEMBL15161955 | 0.69 | SMN1; SMN2 (0.44) | KDM4EALDH1A1CNR1CNR2THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-B1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2015-02-25 | — | — | EP | disclosed |
| EP-2626361-B1 | Pyrrole antifungal agents | F2G LTD (GB) | 2014-10-15 | — | — | EP | disclosed |
| EP-2626361-A1 | Pyrrole antifungal agents | F2G Limited (GB) | 2013-08-14 | — | — | EP | disclosed |
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |